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KMID : 1161420210240040422
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Journal of Medicinal Food
2021 Volume.24 No. 4 p.422 ~ p.430
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Curcumin Promotes Primary Oral Wound Healing in a Rat Model
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Chaushu Liat
Gavrielov Marina Rahmanov
Chaushu Gabi
Zar Keidar
Vered Marilena
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Abstract
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Curcumin is known as an anti-tumor, anti-aging, and wound healing promoter. The aim this study was to examine the effect of 2% curcumin paste application on primary wound healing in a palatal rat model. A mid-crestal incision was initiated on the maxillary alveolar ridge. A full thickness flap was raised on either side of the incision and was then repositioned and sutured. Experimental groups consisted of 2% curcumin (Cur), orabase (O), cut only (C), and intact control?no incision, no paste (N). Curcumin 2% and orabase were applied postoperatively every 12?h for 3 consecutive days. Rats were equally killed after 1 and 2 weeks. Histological data included?epithelial gap, inflammatory infiltrate, myofibroblasts, epithelial and connective tissue stem cell-related markers. Data were collected at two time points?1 and 2 weeks. There was no residual epithelial gap 1 week from incision in the Cur and O group vs. residual gap in the C group (P?=?.031). Curcumin 2% was associated with upregulated expression of epithelial-related markers (P?
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KEYWORD
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curcumin, stem cell markers, wound healing
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